Research Focus
My research interests lie in the use of metabolomics analyses to characterize engineered biosynthetic and metabolic pathways to understand cellular metabolism and its regulation, in vivo. This is directed towards addressing key environmental challenges and engineering robust microbial platforms for producing valuable renewable bioproducts.
Projects
- Understanding how microbes alleviate the burden of accumulated toxic biosynthetic pathway intermediates and products
- Developing efficient, high-throughput metabolomics sample preparation methods for microbial cultures
- Developing high-throughput quantitative LC-MS methods for microbial and plant metabolomic analyses
- Developing high-resolution CE-MS methods for microbial and plant metabolomic analyses
Featured Media
Berkeley Lab researchers discover possible method to reduce cost of biofuels
JBEI Scientists Unravel Omics Data Using Systems Biology-Based Workflow To Improve Biofuels Productivity
Featured Publications
- “Microbial Metabolomics: Methods and Protocols”, Methods in Molecular Biology (2019)
- “Characterizing Strain Variation in Engineered E. coli Using a Multi-Omics-Based Workflow”, Cell Systems (2016)
- “Metabolic engineering for the high-yield production of isoprenoid-based C5 alcohols in E. coli”, Scientific Reports (2015)
- “Metabolic pathway optimization using ribosome binding site variants and combinatorial gene assembly”, App. Microbiol. Biot. (2014)
- “Engineering dynamic pathway regulation using stress-response promoters”, Nat. Biotech. (2013)
- “Mass Spectrometry-based Microbial Metabolomics”, Microbial Systems Biology, Series: Methods in Molecular Biology (2012)