By agreement of all JBEI Partners, Berkeley Lab manages intellectual property and is responsible for collaborative research and licensing agreements to commercialize JBEI technology. Rather than requiring a corporate research sponsor or licensee to negotiate separate agreements with multiple JBEI Partners, this approach enables companies to work with with just one party to access technology developed by the complete suite of JBEI Partners. Companies can more readily access scientific talents and technology developments from five National Laboratories and six academic research partners towards making economically competitive bio-based fuels and chemicals.
JBEI’s innovative culture and cutting-edge advances have resulted in a growing portfolio of intellectual property that is available for licensing. A brief summary of JBEI/Berkeley Lab licensing practices is available here. For additional information on JBEI technologies, and to receive notification of future JBEI inventions, please either go here or contact Robin Johnston at [email protected]
Profiles of Current Technologies Available for Licensing and Collaboration
The list of technologies below are available for licensing or as the foundation for a research collaboration. If you can’t find the technology you’re interested in, please contact Robin Johnston at [email protected].
Recently Added
- Advanced Dissolution and Depolymerization Method to Transform Plastic Recycling 2021-169
- Agrobacterium-Mediated Plant and Fungal Transformation with Refactored Virulence Plasmids 2021-072
- Catalytic Depolymerization of Lignin via Metal Catalysts 2020-148
- Genetically Modified Host Cells for Improved Polyketide Production 2022-152
- High-precision Pipette Tips Compatible with Existing Liquid Handling Robots 2023-014
- Metabolically Engineered Pseudomonas putida for the Bioproduction of Shinorine, a Natural Sunscreen 2021-119
- Non-oxidative Route for Glucose Metabolism in Pseudomonas putida 2020-110
- Water-enhanced Pretreatment of Biomass for High Saccharification Yields 2024-021
- A catalog of Biological Sciences Software available open-source or for licensing can be found here
Advanced Fuels
- 5-Carbon Alcohols for Drop-in Gasoline Replacement EIB-2392, EIB-3112
- ART: A machine learning Automated Recommendation Tool for guiding synthetic biology 2020-011
- Bacterial Overproduction of Methyl Ketones from Sugar EIB-3063
- Biosynthesis Pathways for Five-Carbon Alcohol from Mevalonate 2014-135
- Biosynthetically Produced Pinene for Jet Fuel or Chemical Applications EJIB-2895
- Construction and engineering of novel membrane protein transporters for bioproduction 2021-025
- Controlling Metabolic Pathways Using Artificial Positive Feedback Loop in Yeast EIB-3293
- Converting Depolymerized Lignin into Value-added Products 2015-057
- Custom Engineered Microcompartments for Enzyme Efficiency IB-2626
- Directing Biomolecules to Intracellular Microcompartments and Scaffolds IB-2785
- Efflux Pumps to Increase Microbial Tolerance and Biofuel Production EIB-2845
- Engineered Biosynthesis of Alternative Biodiesel Fuel in E. Coli and Yeast EIB-2391
- Engineering Microbes for Biosynthesis of Terpenes 2016-005
- Enhanced Production of Biofuel Precursors in Microalgae 2013-075
- Enzyme Screening Platform for phosphomevalonate decarboxylase 2016-110
- High-Level Production of Fatty Alcohols from Engineered Yeast 2017-097
- Higher Titer Olefinic Ester Production in Recombinant Escherichia coli 2021-141
- Improving Long Term Storage of Biofuels with Structure-based Engineering of Geranylgeranyl Reductases EIB-2867
- Integrated System for Bio-isoprene Production via Continuous Off-Gas Capture and Dehydration of Isoprenol 2021-096
- Irreversible, Low Load Genetic Switches EJIB-2593
- Microbial-Electrocatalytic System for Hydrocarbon Production IB-3131
- Modified Yeast Strain Imports and Utilizes Xylose as Carbon Source 2014-020
- Non-oxidative Route for Glucose Metabolism in Pseudomonas putida 2020-110
- Novel Biosynthetic Pathway for Production of Fatty Acid Derived Molecules EIB-2386
- Novel Fermentative Production of Precursors for High Energy Biofuels Using Polyketide Synthases 2020-088
- Novel fungal Autoinducible Expression System 2019-174
- Production of Dicarboxylic Compounds from Renewable Sources 2014-158
- Production of Fatty-Acid-Derived Biofuels and Chemicals in Saccharomyces cerevisiae 2013-113
- Rationally Designed Synthetic Transcription Factors EIB-3211
- Synthesized Adipic Acid for Renewable Chemical Production 2015-106
- Specific Reduction of Various Isoprenoid Precursors and Isoprenoids by Geranylgeranyl Reductases 2018-088
- Unique Isoprenoid-like Compounds (Carbon Numbers Not in Multiples of Five) 2014-119
- Using Polyketide Synthases to Produce Advanced Biofuels EJIB-2540
Bioproducts
- A CRISPR-Based and Metabolic Modeling Guided Strategy to Maximizing Indigoidine Production 2019-145
- ART: A machine learning Automated Recommendation Tool for guiding synthetic biology 2020-011
- Base-catalyzed Isomerization of Muconic Acid Derivatives for High Performance Nylon 66 2021-065
- Biological Production of Muconic Acid 2016-140
- Biological Production of Cinnamoyl Anthranilates EIB-2923
- Chelator-Mediated Fenton (CMF) Process to Transform Lignin into a Water-Soluble Polymer without Need for Separation or Concentration Steps 2019-152, 2019-054, 2021-042
- Cholinium Lysinate, an Ionic Liquid, as a Broad Spectrum Herbicide 2018-118
- Construction and engineering of novel membrane protein transporters for bioproduction 2021-025
- Controlling Metabolic Pathways Using Artificial Positive Feedback Loop in Yeast EIB-3293
- Converting Depolymerized Lignin into Value-added Products 2015-057
- Converting Lignin to Ionic Liquids without Reductive Amination 2014-166
- Depolymerizing Lignin Using a Chelator-Mediated Fenton Reaction 2015-029
- Efficient Production of Oxidized Terpenes Via Enzyme Fusion Strategy 2019-108
- Engineered Polyketide Synthases for the Renewable Production of Lactam Analogs 2018-023
- Engineering Bacteria for Wastewater Treatment and Simultaneous Production of Biofuels or Biobased Chemicals EIB-3228
- Engineering Microbes for Biosynthesis of Terpenes 2016-005
- Engineering S. cerevisiae to Produce Isoprenol for Sustainable Aviation Fuel and Chemicals 2020-086
- Enhancing Latex Production 2017-018
- Enzymatic Activation and Cyclization of Hydroxy Fatty Acids for the Production of Alkyl Lactones 2016-054
- Enzymes Enabling Toluene Biosynthesis and Tailoring of Aromatic Compounds 2017-126
- High Production Titers and Rates of Tetramethyl Pyrazine 2018-101
- High Titer Production of Indigoidine in Rhodosporidium toruloides 2018-129
- Higher Titer Olefinic Ester Production in Recombinant Escherichia coli 2021-141
- Host cells and methods for producing unnatural terpenoids using a novel artificial metalloenzyme 2020-049
- Increasing Value of Waste Lignin from Biomass Processing 2013-139
- Introduction of a Synthetic CO2-fixing Photorespiratory Bypass into a Cyanobacterium 2013-020
- Ionic Liquids from Lignin-derived Compounds EIO-2013-042
- JBEI Polyketide Synthases Portfolio for Production of Chemicals and Fuels EJIB-2820, EJIB-2825, EIB-2878, EJIB-2982, EJIB-3014
- Metabolically Engineered Pseudomonas putida for the Bioproduction of Shinorine, a Natural Sunscreen 2021-119
- Magnetically Recoverable ZIF Catalysts for the Efficient Depolymerization of Polyesters 2018-055
- Non-oxidative Route for Glucose Metabolism in Pseudomonas putida 2020-110
- Novel Enzymatic Process for the Production of Hydrogen Peroxide 2019-107
- Novel Fermentative Production of Precursors for High Energy Biofuels Using Polyketide Synthases 2020-088
- Novel fungal Autoinducible Expression System 2019-174
- Novel Method to Depolymerize Lignin through Sulfonation and Chelator-mediated Fenton Reactions 2021-077
- Producing 3-Hydroxycarboxylic Acids and Ketones using PKS 2014-007
- Producing Beneficial Materials from Biomass and Biodiesel Byproducts IB-2379
- Production of 1-deoxyxylulose-5-phosphate (DXP) EIO-3006
- Production of 4-Vinylphenol for Bioplastics 2021-122
- Production of Fatty-Acid-Derived Biofuels and Chemicals in Saccharomyces cerevisiae 2013-113
- Production of omega-hydroxy methyl ketones as precursors for the synthesis of high value fragrances and novel materials 2015-141
- Renewable Chemicals Produced from Lignin EIO-3265
- Specific Reduction of Various Isoprenoid Precursors and Isoprenoids by Geranylgeranyl Reductases 2018-088
- Synthesis of Biofuels and Chemicals via Triketide Lactones, Engineered Through Polyketide Synthases (PKSs) 2020-057
- Synthesis of Renewable Deep Eutectic Solvents from Lignin-Derived Phenolic Compounds 2017-060
- Systematic Engineering of Methylomicrobium alcaliphilum Strain for Production of Rhamnolipid (RLs) Biosurfactants 2019-167
- High-Level Production of Fatty Alcohols from Engineered Yeast 2017-097
- Unique Isoprenoid-like Compounds (Carbon Numbers Not in Multiples of Five) 2014-119
Deconstruction
Pretreatment
- A One-Pot Biomass Conversion Process Using Deep Eutectic Solvents 2016-160
- Ammonium-based Ionic Liquids for Lignocellulosic Processing 2014-167
- Catalytic Depolymerization of Lignin via Metal Catalysts 2020-148
- Chelator-Mediated Fenton (CMF) Process to Transform Lignin into a Water-Soluble Polymer without Need for Separation or Concentration Steps 2019-152, 2019-054, 2021-042
- Converting Lignin to Ionic Liquids without Reductive Amination 2014-166
- Converting Monomeric, Oligomeric, and Polymeric Lignin into Ionic Liquids 2015-055
- Derivitization of Sugars into Ionic Liquids 2015-059
- Double Salt Ionic Liquids for Efficient Biomass Pretreatment 2020-084
- Economical “In Situ” Ionic Liquid and Deep Eutectic Solvent Synthesis 2019-104
- Engineering S. cerevisiae to Produce Isoprenol for Sustainable Aviation Fuel and Chemicals 2020-086
- Ensiled Biomass to Increase Ionic Liquid Pretreatment Efficiency 2019-102
- Ionic Liquids from Lignin-derived Compounds EIO-2013-042
- Metal Chloride Deep Eutectic Solvents for Economical Biomass Fractionation 2019-092
- Novel Method to Depolymerize Lignin through Sulfonation and Chelator-mediated Fenton Reactions 2021-077
- Production of omega-hydroxy methyl ketones as precursors for the synthesis of high value fragrances and novel materials 2015-141
- Switchable Ionic Liquids for Biomass Pretreatment and Enzymatic Hydrolysis 2014-064
- Tunable pH Ionic Liquids for Pretreatment of Lignocellulosic Materials 2015-096
- Water-enhanced Pretreatment of Biomass for High Saccharification Yields 2024-021
Enzymes
- A Plant-Fungal Hybrid Peroxidase Engineered for Enhanced Activity and Stability 2016-070
- Cellulose Degradation Using Sulfolobus Enzymes IB-3106
- Cellulose and Hemicellulose Degrading Activity in Fungal Laccases: A Method for Biomass Deconstruction 2019-151
- Halophilic and Thermostable Cellulases Tolerant to Ionic Liquids EJIB-3028
- JTherm for Enhanced Deconstruction of Lignocellulosic Biomass 2015-010
- Identification of Gene Targets for Improved Heterologous Enzyme Production in Aspergillus Niger 2017-118
- Ionic Liquid-tolerant Cellulase Enzymes EJIB-3264
- Ligninolytic Enzyme Production CIB-2835
- Multi-functional Enzymes for Hydrolysis of Glucan, Mannan and Xylan EJIB-3057
- Novel Thermophilic Cellobiohydrolase EIO-2745
- Thermophilic Cellulases Compatible with Ionic Liquid Pretreatment EJIB-2666
- Thermophilic Endoglucanase Enzymes Engineered for Increased Activity EIO-2667
Process Integration
- A One-Pot Biomass Conversion Process Using Deep Eutectic Solvents 2016-160
- Acid Hydrolysis of Biomass and Increased Sugar Recovery by Solvent Extraction EJIB-3030
- Consolidated Conversion of Biomass into Biofuels using Ionic Liquids 2014-139
- Engineered Bacterium with Resistance to Ionic Liquid EJIB-3127
- Engineered Microorganisms Resistant to Ionic Liquids 2013-120
- Fractionation and Removal of Solutes from Ionic Liquids EJIB-2729
- Long Alkyl Chain Alcohols as Co-solvent, Precipitant, and Extraction Medium in Ionic Liquid Pretreatment 2013-105
- Low Temperature Lignin Dissolution, Depolymerization 2015-080
- Recovery of Sugars by Solvent Extraction EJIB-2750
- Streamlined Saccharification from Lignocellulosic Biomass 2015-143
- Sugar Extraction and Ionic Liquid Recycling Using Alkaline Solutions EJIB-3117
- Synthesis of Renewable Deep Eutectic Solvents from Lignin-Derived Phenolic Compounds 2017-060
Feedstocks
- Agrobacterium-Mediated Plant and Fungal Transformation with Refactored Virulence Plasmids 2021-072
- Biological Production of Muconic Acid 2016-140
- Cholinium Lysinate, an Ionic Liquid, as a Broad Spectrum Herbicide 2018-118
- Creation of Heritable Traits in Chimeric Plants IB-2013-171
- Dominant Negative Mutations of Arabidopsis 2013-051
- Dominant Suppression of Xylan Biosynthesis Using IRX10 Catalytic Mutants 2017-008
- Energy Crops Engineered for Increased Sugar Extraction through Inhibition of snl6 Expression EIO-2763
- Engineering Bioenergy Crops for Integrated Co-bioproduction of Fuels and Key Value Chemicals 2015-138
- Engineering Competitive Pathways for Tissue-Specific Lignin Reduction EIB-3266
- Enhancing Latex Production 2017-018
- Feedstocks With Reduced Acetylation for Higher Product Yields and Improved Properties EIB-2658
- Folium: Tobacco as a Platform for Foliar Biosynthesis of Advanced Hydrocarbon Fuels
- Gene Modification to Increase Drought and Flood Tolerance in Plants 2014-108
- Golgi Nucleotide Sugar Transporters as Tools for Cell Wall Modification 2013-092
- Increased Production of Storage Compounds in Seeds 2016-103
- Improved Crops with Increased Galactan Content EIB-3144
- Improved Xylan Extraction EJIB-2915
- Improving Saccharification Efficiency by Inhibiting a Xylosyltransferase EJIB-3136
- Lignification Stoppers EIB-2929
- Marker-free Gene Insertion in Plants via CRISPR-Cas9 2019-055
- New Synthetic Transcription Factors and Promoters to Modulate Transgene Expression Strength 2019-100
- Production of PDC in Plants Via Heterologous Expression of Bacterial Genes 2019-069
- Reduction of Cell Wall Methylation and Recalcitrance 2016-141
- Synthetic transcription factor systems for enhanced control of gene expression 2021-082
- Synthetic Promoters Useful for Expression in Plant Cells 2015-049
- Translation Control Tool for Plant Bioengineering 2013-166
Research Tools and Software
A catalog of Biological Sciences Software available open source or for licensing can be found here
- Arrowland: An Online Multiscale Interactive Tool for -omics Data Visualization 2016-102
- ART: A machine learning Automated Recommendation Tool for guiding synthetic biology 2020-011
- Contactless Loading to a Microfluidic Chip 2019-078
- Determining Ligninases Activities through Nanostructure Initiator Mass Spectrometry (NIMS) 2016-109
- Directed Evolution of Microbe Producing Biofuels Using In Vivo Transcription Factor Based Biosensors EJIB-2710
- DNA Construction by Single-molecule Assembly of Capped DNA Units 2013-188
- Gold Nanoparticle Film for Nanostructure-Initiator Mass Spectrometry (NIMS) 2017-036
- High-precision Pipette Tips Compatible with Existing Liquid Handling Robots 2023-014
- Lab-on-a-chip Device for Massively Parallel DNA Assembly and Functional Screening EJIB-2934
- Lanthanide-Chelator Barcode for Combinatorial Screening Applications 2016-121
- Library of Plasmids to Control Gene Expression Levels EIB-2792
- Massive Scale Enzyme Screening Using Picoliter Droplet Array on Nanostructure-Initiator Mass Spectrometry 2019-097
- microNIMS for Enzyme Assay 2016-049
- NIMS-based Multiplexed Enzymatic Assays EJIB-2926
- Parallel Droplet Manipulation and Digital Microfluidic Droplet Generation, Transport, Splitting and Merging 2017-052, 2017-053
- Precise, High Throughput Droplet Manipulation 2013-128
- Predicting Metabolic Pathway Dynamics from Time Series Multiomics Data Using Machine Learning Techniques 2017-049
- Production of Bacterial Microcompartments for Synthetic Biology Applications IB-2013-014
- Rapid Discovery and Optimization of Enzyme Solutions Using Tagged Biomass and Mass Spectrometry EJIB-3262
- Single Biorefinery Reactor Vessel for Performing Multiple Pretreatments 2013-047
- Toaster Software: Optimizing CRISPR Technologies for Genome Editing 2016-056
Synthetic Biology Tools
- A System for Homogenous Editing of Mitochondrial Chromosomes 2017-153
- Agrobacterium-Mediated Plant and Fungal Transformation with Refactored Virulence Plasmids 2021-072
- New Synthetic Transcription Factors and Promoters to Modulate Transgene Expression Strength 2019-100
- Promoter Useful for High Expression of a Heterologous Gene of Interest in Aspergillus Niger 2016-092
- Synthetic transcription factor systems for enhanced control of gene expression 2021-082