New Pathways and Metabolic Models

The mission of the New Pathways and Metabolic Models Department at JBEI is to select, develop, and demonstrate efficient conversion strategies to transform biomass-derived sugars and aromatics into infrastructure- and engine-compatible biofuels, as well as into drop-in and novel bioproducts. To develop biosynthetic and hybrid biological-chemical (semisynthetic) pathways to a variety of prioritized biofuels and bioproducts JBEI scientists are 1) developing a retrobiosynthesis pathway predictor that will enable prioritized selection of biological pathways, enzymes, and chemical transformations to produce a desired target; 2) developing biosynthetic pathways to the desired targets or to intermediates that can be converted using chemistry into the desired biofuel or bioproduct; and 3) developing and testing a number of chemical transformations from biologically produced intermediates to the desired biofuel or bioproduct.

Projects

  • Development of a retrobiosynthesis pathway predictor that will enable prioritized selection of biological pathways, enzymes, and chemical transformations to produce a desired target
  • Development of synthetic biology pathways to the desired biofuel or bioproduct (r intermediates) using modular pathways such as the polyketide synthases
  • Development of mechanistic and non-mechanistic models for optimizing flux through engineering metabolic pathways

Featured Media

Metabolic Engineering of Lipids Improves the Respiratory Function of Biofuels and Bioproducts Hosts

Faster, Cheaper, Better: A New Way to Synthesize DNA

Turning Sugar into High Performance Fuel: CNN’s The Next List Profiles Jay Keasling

Jay Keasling Wins Heinz Award

Jay-@-JBEI

Featured Publications

Featured Intellectual Property